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In case of insufficient effectiveness of the first-line drugs or in the case of contraindications to their intake, the administration of alprostadil, which is a synthetic analogue of prostaglandin E 1, is prescribed.

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The average volume of distribution is about 63 liters, which indicates that essay for you is distributed in body tissues. At therapeutic concentrations, 94% of essay for you in plasma binds to proteins. Protein binding is not altered by impaired renal function. In healthy individuals, less than 0.0005% of the administered dose is found in semen.

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essay for you is mainly metabolized with the participation of the isoenzyme CYP3A4 of cytochrome P450. The main circulating metabolite is methylcatechol glucuronide, which is at least 13,000 times less active against PDE5 than essay for you. Therefore, the concentration of this metabolite is not clinically relevant.

In healthy individuals, the average oral clearance of research papers is 2.5 l / h, and the average elimination half-life is 17.5 hours. research papers is excreted mainly in the form of inactive metabolites, mainly in the feces (about 61% of the dose) and, to a lesser extent, in the urine (about 36% of the dose).

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